Scientific Publications and media reports describing research undertaken with NCRIS support through APN Partners and Nodes

Cell Death and Differentiation. In Press

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.

Brasacchio D, Alsop AE, Noori T, Kluck RM, Simpson KJ, Bird PI, Johnstone RW and Trapani JA.


Nature Communications. In Press

Host cell signalling responses to early stages of hepatitis C virus replication.

Haqshenas G, Wu J, Simpson KJ, Daly RJ, Netter HJ, Baumert TF and Doerig,C.


Scientific Data, 2017 February

High-content genome-wide RNAi screens for regulators of endothelial cell migration and morphology.

Williams SP, Gould CM, Nowell CJ, Simpson KJ, and Stacker SA.


Assay Drug Dev Technology. 2017 Jan

HCS/HCA 3D Imaging: Best Practices and Unmet needs colloquium.

Hoffman AF, Simpson KJ, Horvath P, Lovitt C, Silvers S, Easton E, LaBarbera DV, Mendez M, Rothenberg ME, Seldin J, Wardwell-Swanson J, Fennell M.


Plos Pathogens, 2016

Genome-wide siRNA Screening at Biosafety Level 4 Reveals a Crucial Role for Fibrillarin in Henipavirus Infection.

Deffrasnes C, Marsh GA, Foo CH, Rootes CL, Gould CM, Grusovin J, Monaghan P, Layton DS, Tompkins M, Adams TE, Lowenthal JW, Simpson KJ, Stewart CR, Bean AGD and Wang L-F.


Assay Drug Dev Technol. 2016 Oct

A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization.

Smith LK, Thomas D, Simpson KJ, Humbert PO.


PLoS Pathog. 2016 Oct

Dual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion.

Chwan Hong Foo, Christina L. Rootes, Karla Cowley, Glenn A. Marsh, Cathryn M. Gould, Celine Deffrasnes, Chris J. Cowled, Rueben Klein, Kaylene J. Simpson, Lin-Fa Wang, Andrew G. D. Bean and Cameron R. Stewart.


Assay Drug Dev Technology. 2016 Oct

Society of Biomolecular Imaging and Informatics Special Issue, Oct 2016

Fennell M and Simpson KJ.


Assay Drug Dev Technol. 2016 Sep

Society of Biomolecular Imaging and Informatics Special Issue, Sept 2016

Fennell M, Simpson KJ.


Assay Drug Dev Technology, 2016 Sep

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.

Chan KT, Paavolainen L, Hannan KM, George AJ, Hannan RD, Simpson KJ, Horvath P, Pearson RB.


Int J Parasitol Drugs Drug Resist. 2016 Aug

Metabolic profiling and in vitro assessment of anthelmintic fractions of Picria fel-terrae Lour.

Kumarasingha R, Karpeb AV, Preston S, Yeod T-C, Lim DSL, Tu, C-L, Luu J, Simpson KJ, Shaw JM, Gasser RB, Beale DJ, Morrison PD, Palombo EA, Boag PR.


Cell Death and Differentiation 2016 Feb

A genome scale siRNA screen reveals GLI1 as a novel gene regulating vorinostat sensitivity.

Falkenberg KJ, Gould CM, Luu J, Matthews GM, Simpson KJ and Johnstone RW.


Virology, 2016 Feb

Phosphorylation of NS5A Serine-235 is essential to hepatitis C virus RNA replication and normal replication compartment formation.

Eyre NS, Hampton-Smith RJ, Aloia AL, Eddes JS, Simpson KJ, Hoffmann P and Beard MR.


Nature Communications 2016 Feb

CARD: an interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

Dutta B, Azhir A, Merino L-H, Guo Y, Revanur S, Madhamshettiwar P, Germain RN, Smith JA, Simpson KJ, Martin SE, Beuhler E and Fraser IDC.


 Nature. 2015 Oct 29

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

Kayagaki N, Stowe IB, Lee BL, O’Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM.


Proc Natl Acad Sci U S A. 2015 Sep 15

Comparison of predicted and actual consequences of missense mutations.

Miosge LA, Field MA, Sontani Y, Cho V, Johnson S, Palkova A, Balakishnan B, Liang R, Zhang Y, Lyon S, Beutler B, Whittle B, Bertram EM, Enders A, Goodnow CC, Andrews TD.


PLoS Genet. 2015 Oct 23 (Erratum in: PLoS Genet. 2015 Dec)

HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.

Lim SL, Qu ZP, Kortschak RD, Lawrence DM, Geoghegan J, Hempfling AL, Bergmann M, Goodnow CC, Ormandy CJ, Wong L, Mann J, Scott HS, Jamsai D, Adelson DL, O’Bryan MK. Read


Special Issue, Assay, Drug Development Technologies. 2015 Nov

Colloquium: SBI2 HCS/HCA Informatics and Data analysis – best practices and unmet needs.

Fennell M, Simpson KJ. Society of Biomolecular Imaging and Informatics.


 Assays, Drug Development Technologies. 2015 Nov

Colloquium: SBI2 HCS/HCA Informatics and Data analysis – best practices and unmet needs.

Bowman D, Fennell M, Simpson KJ.


Assay, Drug Development Technologies. 2015 Sep

Society of Biomolecular Imaging and Informatics special issue

Fennell M, Simpson KJ.


Assays, Drug Development Technologies, SBI2 special issue. 2015

High-content assay for measuring intracellular growth of Leishmania spp. in human macrophages.

Michael J. Dagley, Eleanor C. Saunders, Kaylene J. Simpson^ and Malcolm J. McConville^ ^equal senior author.


Cell Tissue Res 359

Differences in hormone expression patterns of K-L enteroendocrine cells in the mouse and pig small intestine and colon

Cho HJ, Kosari S, Hunne B, Callaghan B, Rivera LR, Bravo DM, Furness JB (2015).


J Neurogastroenterol Motil. 21

Surgical intervention to rescue Hirschsprung disease in a rat model

Stamp LA, Obermayr F, Pontell L, Young HM, Xie D, Croaker D, Song Z-M, Furness JB (2015)


Frontiers in Neuroanatomy

Transient receptor potential cation channel subfamily V member 1 expressing corneal sensory neurons can be subdivided into at least three subpopulations

Alamri A , Bron R, Brock JA, Ivanusic JJ (2015)


Nat Commun. 2014

Maspin is not required for embryonic development or tumour suppression.

Teoh SS, Vieusseux J, Prakash M, Berkowicz S, Luu J, Bird CH, Law RH, Rosado C, Price JT, Whisstock JC, Bird PI.


Molecular Autism

Brinp1−/−mice exhibit autism-like behavior, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density.

Berkowicz SR, Featherby TJ, Qu Z, Giousoh A, Borg NA, Heng JI, Whisstock JC, Bird PI (2016)