The European Conditional Mouse Mutagenesis Program (EUCOMM) is a founder member and European cornerstone of the International Knockout Mouse Consortium (IKMC). EUCOMM’s main objective is the generation, archiving, and world-wide distribution of up to 12,000 conditional mutations across the mouse genome in mouse embryonic stem (ES) cells.
The International Gene Trap Consortium (IGTC) represents all publicly available gene trap cell lines, which are available on a non-collaborative basis for nominal handling fees. Researchers can search and browse the IGTC database for cell lines of interest using accession numbers or IDs, keywords, sequence data, tissue expression profiles and biological pathways.
The members of the International Knockout Mouse Consortium (IKMC) are working together to mutate all protein-coding genes in the mouse using a combination of gene trapping and gene targeting in C57BL/6 mouse embryonic stem (ES) cells. The IKMC includes KOMP, NorCOMM, EuCOMM and the Texas A&M Institute for Genomic Medicine (TIGM) (USA).
The IMPC builds on the efforts of IKMC to produce knockout mice and carry out high-throughput phenotyping of each line in order to determine the function of every gene in the mouse genome. These mice will be preserved in repositories and made available to the scientific community representing a valuable resource for basic scientific research as well as generating new models for human diseases.
The Knockout Mouse Project (KOMP) is a result of the trans-NIH initiative that aims to generate a comprehensive and public resource comprised of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome. The KOMP Repository is a collaborative effort between the Children’s Hospital Oakland Research Institute (CHORI) and the University of California, Davis (UC Davis), to preserve, protect, and make available products of 8,500 targeted genes generated from the KOMP project.
NorCOMM (North American Conditional Mouse Mutagenesis project) is a large-scale research initiative focused on developing and distributing a library of mouse embryonic stem (ES) cell lines carrying single gene trapped or targeted mutations across the mouse genome. Supported by a major grant from Genome Canada, NorCOMM unites expertise in cellular and functional genetics at academic centres across the country; including the Embryonic Stem Cell/Targeted Mutagenesis Facility (Univeristy of Calgary) Mammalian Functional Genomics Centre (University of Manitoba), the Centre for Modeling Human Disease (University of Toronto), the Canadian Mouse Mutant Repository (Toronto), and The Hospital for Sick Children (Toronto).