Genomics
A range of high-throughput sequencing platforms is available through our network.
A range of high-throughput sequencing platforms is available through our network.
The APN’s genomic and bioinformatics specialists provide a comprehensive range of services, and tools not otherwise available in standard sequencing services, including:
The APN’s high throughput screening service offers cutting edge genomics (CRISPR, RNAi), compound screening and proteomics technologies for gene discovery and investigation of gene function. This gives researchers the opportunity to study loss-of-function genetics and identify novel genes of interest prior to developing specific animal models.
Our key platforms support gene discovery through gene suppression (RNAi) or gene knockout (CRISPR) strategies, generally coupled with detailed quantitative cellular phenotypic high content imaging. Quantitation of protein expression and posttranslational modification is also available through the Reverse Phase Protein Array platform with over 100 antibodies available for analysis in our collection, which continues to expand.
The Histopathology and Organ Pathology Service helps researchers across Australia in histological preparation, analysing histology images and data on genetically modified animals. It generates histological and organ pathology data on mouse models created through APN.
The APN provides state-of-the-art high volume instrumentation to study cells, chemical and biochemical mechanisms through body fluids such as blood or urine. Equipment includes:
Routine clinical chemistry & special tests such as specific proteins & drug monitoring
Cytokines, chemokines & phosphoprotein products
Complete blood cell, white blood cell differential and reticulocyte count
Cellular analysis of blood cells
The APN team provides management to define, plan and execute projects. This includes production of gene variant mice, coordinating and performing demanding phenotyping assays, and providing a range of data management and analysis expertise and services.