The Australian Phenomics Facility at the Australian National University in Canberra was established in 2005. It specialises in the development, characterisation and archiving of mouse models of human disease. It supports open access large-scale phenotyping of humans and mice to uncover the biological drivers in human disease.
The Animal Resources Centre (ARC) is a self-funding Statutory Authority of the Government of Western Australia and for over 35 years has supported Australian and regional Asia-Pacific biomedical research, teaching and testing by producing and supplying genetically-defined, specific pathogen free (SPF) research rats and mice. The outbred, inbred, mutant, hybrid and congenic lines of mice and rats supplied by the Animal Resources Centre meet the exacting world-class demands of contemporary biomedical research via state-of-the-art animal health monitoring, genetic testing, quality assurance, and specialist production and maintenance expertise. The ARC also offers a cluster of services to customers including cryopreservation and custom rat and mouse strain maintenance.
The Harry Perkins Institute of Medical Research was established in 1998 and is a collaboration of Western Australian medical researchers.
Monash University hosts the Embryonic Stem (ES) Cell to Mouse, and Cryopreservation nodes of APN.
A world-leading cancer research centre, active in treatment, cliniciantraining and medical research. The Victorian Centre for Functional Genomics (VCFG) is a national facility that enables high throughput RNAi and CRISPR mediated discovery-based screening using either plate-reader based analysis or advanced quantitative high content imaging. The VCFG also operates a quantitative Reverse Phase Protein Array platform to quantify the expression of native and phospho proteins.
https://www.petermac.org/research/core-facilities/victorian-centre-functional-genomics
Established in 2008, SAHMRI is a collaborative partnership of South Australia’s basic and translational research capabilities, including SA’s three universities and the health system. SSAHMRI is a service node for APN’s CRISPR gene editing service.
The APN Mouse Histopathology and Digital Slide Service helps researchers across Australia in histological preparation, analysing histology images and data on genetically modified animals. It generates histological and organ pathology data on mouse models created through APN.
The Melbourne Advanced Genome Editing Centre (MAGEC) was established in 2013 at WEHI by Dr Marco Herold and his lab, with the aim of developing CRISPR/Cas9 technology for gene editing. The lab was able to adapt the CRISPR/Cas9 system into a novel inducible lentiviral platform for rapid and efficient modification of genes in cell lines and primary cells (Aubrey et al., Cell Reports 2015). During this time, MAGEC successfully translated their expertise in CRISPR/Cas9 technology into the generation of gene-targeted mice.